Sedating antihistamines for insomnia

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I've heard a few people telling me they take antihistamines to help them to get to sleep.Has anyone else tried this and if so, have they worked for you?H2 blockers (eg, ranitidine, famotidine) commonly are used for the treatment of heartburn and gastroesophageal reflux disease.These medications decrease gastric acid secretion in the stomach by antagonizing the effects of histamine at H2 receptors found in gastrointestinal parietal cells.In this study, people either took diphenhydramine or a placebo.The diphenhydramine group switched to a placebo after two weeks.Another one I like to use is hydroxyzine (also known as Vistaril or Atarax) but that is only available as a prescription, however its metabolite is Zyrtec, which is OTC. Read more You become tolerant to the sedative effect of first generation antihistamines and with time you will no longer feel sedated from them.

These sedating antihistamines often are used alone or in combination with other ingredients in cold and cough medications, and over-the-counter (OTC) sleep aid products.

The term “antihistamine” generally is used to describe those medications that antagonize histamine activity at H1 receptors.

Currently the only FDA-approved histamine antagonist medications block the effects of histamine at H1 or H2 receptor sites.

Dear Doctor: I’m leery of sleep drugs, so I’ve been taking Benadryl to help me sleep.

Now I read that it should be taken only for a limited time. Dear Reader: Diphenhydramine HCL, or Benadryl, is a sedating antihistamine.

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